actually come to think of it, it might be the VS. mine did that with the VS you appear to be using. but i didn't have calibri, i had corbel running... try switching the VS
There are different versions of Calibri: an older version circulated last year, along with five other Vista fonts. A newer version came out with the Office 2007 beta 2. I don't know what *all* the differences are, but in the older version, the numbers 0-9 were off-centred; in the newer version, all the numbers are even.